AB0146 HAND AND WRIST ACTIVE RANGE OF MOTIONS AND CONTRIBUTING FACTORS IN RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL STUDY

Background: Patients with rheumatoid arthritis (RA) usually impaired range of motions (ROMs), especially hand and wrist active ROMs (AROMs), thus influencing their ability to perform daily activities health-related quality life (HR-QoL). However, little is known about the potential factors reduced AROMs relations in Chinese RA patients. Objectives: To explore contributing associations HR-QoL functional limitation population. Methods: In this cross-sectional study, 108 patients were enrolled from Affiliated Hospital Nantong University between November 2018 July 2019. We measured all participants’ different directions both sides, including volar flexion, ulnar deviation, radial deviation joint, first metacarpophalangeal (MCP1) interphalangeal (IP) abduction, abduction thumb opposition (cm) thumb, average hypertension MCP2-5, proximal (PIP) 2-5 distal (DIP) flexions, total motion (TAM) second fifth fingers (TAM2-TAM5). Their sociodemographic, physical, psychological, disease-related data, acute phase reactants, laboratory indicators, drug usage examined as well. Statistical analysis used Pearson’s Spearman’s correlation analysis, univariate multivariate linear regression analyses. Results: analyses, we found that living rural area, longer disease duration, comorbidity, hospitalization, more swollen joints, higher activity, pain level, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), red blood cell count glucocorticoids associated most decreased ( P ≤ 0.050), while education annual income related increased 0.048). duration 0.023) activity 0.033) corelated AROMs. Interestingly, psychological factor, anxiety, was only positively analyses 0.001). Additionally, declined impairment poor HR-QoL, physical components < 0.05). Conclusion: Various factors, AROMs, causing Clinical physicians medical faculties should pay attention symptoms these order maintain (ADL) improve HR-QoL. References: [1]Rheumatoid arthritis. Nat Rev Dis Primers. 2018;4:18002. [2]Zhang L, Cao H, Zhang Q, Fu T, Yin R, Xia Y, et al. Motion joints patients: a study. BMC Musculoskelet Disord. 2018;19(1):270. Acknowledgements: This work funded by Postgraduate Research & Practice Innovation Program Jiangsu Province (Grant/Award number: KYCX19_2071), National Natural Science Foundation China 81871278, technology Project BE2018671) Disclosure Interests: None declared